How poor sleep could be linked to Alzheimer's

How poor sleep could be linked to Alzheimer's

Studies have previously linked gum disease and dementia.

This study involved a series of experiments on human brain tissues in the laboratory and on mice. "This provides hope of treating or preventing Alzheimer's disease one day", says Singhrao.

The scientists looked at patterns of neuropsychological deficits, vascular risk factors and neuropathological differences between the Hispanic and non-Hispanic patients, who were matched by age, education, global mental status and severity of functional decline at first diagnosis. "I'm fully on board with the idea that this microbe could be a contributing factor".

"Now, for the first time, we have solid evidence connecting the intracellular gram-negative pathogen Pg (P. gingivalis) and Alzheimer's pathogenisis, while also demonstrating the potential for a class of small molecule therapies to change the trajectory of the disease".

A new study could potentially change the way Alzheimer's is detected.

Almost six years ago, Lynch received a call from Stephen Dominy, a psychiatrist at the University of California, San Francisco, who had studied the link between HIV and dementia. Some had HIV-related dementia that resolved after they got antiviral drugs. "Using this very defined patient population we were able to identify affected family members over a decade before they began to show cognitive impairments".

Dr James Pickett, head of research at Alzheimer's Society, said: "The laboratory work does suggest that this infection could cause damage to cells of the brain but there isn't yet clear evidence that it can cause this damage in people or result in Alzheimer's". That early appearance is important, Lynch says, because "you would expect it to be there before the onset" of symptoms. P. gingivalis causes periodontitis, an infection that destroys the gums and can lead to tooth loss.

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But even more compellingly, the team identified these toxic gingipains in the brains of deceased people who were never diagnosed with Alzheimer's. They used a compound that targeted the gingipains, which likely supply nutrients to the bacteria, to successfully kill off the bacteria, reducing neurodegeneration and the formation of beta-amyloid protein. Additionally, while the study was not powered for significance, COR388 showed positive trends across several cognitive tests in patients suffering from AD. Cortexyme plans to initiate a large Phase 2/3 clinical trial of COR388 in mild to moderate AD in 2019.

"Infectious agents have been implicated in the development and progression of Alzheimer's disease before", Dominy said in a statement.

These findings emerged from a study conducted at the Washington University School of Medicine (WUSM), St. Louis. "These are unusual ideas, but they seem to be getting some traction".

Manager of Education and Outreach at the Alzheimers Association, Mayra Ligeza, spoke to the Downers Grove Library informing an audience of more than 30 people about the malignant disease. Results showed mouse ISF tau was increased by up to 90% during wakefulness vs sleep and up to 100% during SD; human CSF tau increased over 50% during SD; in tau seeding and spreading model chronic SD increased tau pathology spreading; chemogenetically driven wakefulness in mice significantly increased ISF Aβ and tau. However, the second theory is the most concerning one.

P. gingivalis infection was thought to fuel high levels of beta- amyloid that eventually became toxic. But he's skeptical that the bacteria or its toxin directly cause Alzheimer's.

In people with Alzheimer's, tau tangles tend to populate parts of the brain important for memory, such as the hippocampus, before spreading to other areas.

This new understanding opens up new potential drug targets. Clinical trials on Alzheimer's patients will be carried out this year. They did not resist the gingipain blockers. Not necessarily. But if healthy people want to stay on the safe side and potentially reduce their risk, Noble says, "the main conclusion we still have is: brush and floss".

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